However, female rats display less anxiety following PCP withdrawal, whereas the opposite effect is evident in male rats Turgeon et al. Bioidentical hormone replacement is effective at alleviating symptoms of hormonal imbalance. With regard to genetic models of schizophrenia, several mutant mouse models have been studied in combination with environmental factors Desbonnet et al.
Intranasal immune challenge induces sex-dependent depressive-like behavior and cytokine expression in the brain. Table 7 Sex differences in models of bipolar disorder. On the other hand, medical conditions implicated in orgasm disorders include pelvic floor dysfunction; neurologic disorders involving both the peripheral e.
For Canine sex hormone imbalance in Arlington of the lateral hypothalamus it has been reported that male rats have higher response rates than female rats aged 15—45 days Velley canine sex hormone imbalance in Arlington Cardo,
Expert Opin Drug Metab Toxicol. Yes No. Canine sex hormone imbalance in Arlington link. In contrast, startle responsivity is suppressed when female rats are stressed and tested in oestrous Harvey et al. Rates and risk of postpartum depression-A meta-analysis. Based on the notion that twin girls with an opposite-sex male twin have a higher exposure to testosterone during fetal life, Cohen-Bendahan and colleagues investigated functional cerebral lateralization in same-sex and opposite-sex twin girls, observing that girls with a male twin had a more masculine pattern and supporting the case of an influence of prenatal testosterone on early brain organization in women Cohen-Bendahan et al.
Enhanced latent inhibition in dopamine receptor-deficient mice is sex-specific for the D1 but not D2 receptor subtype: implications for antipsychotic drug action. The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus.
Psychopharmacology Berl ; 3 — Female animals show preservation behaviour for one arm of the maze, which is highest at late dioestrous and prooestrous and lowest at the oestrous phase Agrati et al. Hum Psychopharmacol.
Central allopregnanolone is increased in rat pups in response to repeated, short episodes of neonatal isolation. The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus.
The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats. In particular, prenatal and pubertal exposure to testosterone influences spatial abilities, emotion and reward processing, and vulnerability to psychiatric disorders.